Signal-decoding at the Xist locus

Date

Sep 7, 2023

Time

11:00 AM - 12:00 PM

Speaker

Edda Schulz

Affiliation

Max Planck Institute for Molecular Genetics, Berlin, Germany

Series

MPI-CBG Thursday Seminar

Language

en

Main Topic

Biologie

Host

Christoph Zechner

Description

To generate the complex expression patterns required to build multicellular organisms, genes decode multiple signals to precisely tune their transcriptional output. A gene's cis-regulatory landscape, usually consisting of a series of regulatory elements (RE), must thus sense the activity of multiple transcription factors (TF) and integrate them in a specific manner. To investigate information processing, we use the Xist gene as a model, which governs X-chromosome inactivation. Xist integrates information on X-chromosomal dosage and developmental stage to trigger X inactivation during early embryonic development in females only. By combining various CRISPR screening approaches we dissect how Xist’s cis-regulatory landscape integrates input from a series of transcription factors to establish the correct expression pattern.

Last modified: Sep 8, 2023, 7:40:00 AM