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UID:DSC-20598
DTSTART;TZID=Europe/Berlin:20240321T110000
SEQUENCE:1711089394
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20240321T120000
URL:https://dresden-science-calendar.de/calendar/en/detail/20598
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Brennecke: The co-evolution of endogenous retroviruses with the ani
 mal germline
CLASS:PUBLIC
DESCRIPTION:Speaker: Julius Brennecke\nInstitute of Speaker: IMBA Vienna\nT
 opics:\n\n Location:\n  Name: MPI-CBG (MPI-CBG Auditorium (big half))\n  S
 treet: Pfotenhauerstraße 108\n  City: 01307 Dresden\n  Phone: +49 351 210
 -0\n  Fax: +49 351 210-2000\nDescription: Small RNA-mediated silencing pat
 hways are essential players in the relentless genetic conflict between tra
 nsposable elements and host genomes. In animal gonads\, the PIWI-interacti
 ng RNA (piRNA) pathway enforces effective transposon silencing in the cyto
 plasm and nucleus. Conceptually similar to prokaryotic CRISPR/Cas systems\
 , the piRNA pathway uses effector proteins complexed with single-stranded 
 guide RNAs (22-32nt piRNAs) derived from genomic loci\, which act as adapt
 ive and heritable sequence repositories. In my seminar\, I will focus on t
 he adult ovary ‘ecosystem’ in Drosophila melanogaster and provide an o
 verview of our current understanding of the piRNA pathway. I will discuss 
 how the rare event of an LTR element gaining infectivity allowed a genuine
  endogenous retrovirus to temporarily escape piRNA-mediated silencing\, re
 sulting in a profound example of retroviral diversification\, and how the 
 host responded.
DTSTAMP:20260411T180510Z
CREATED:20240315T063906Z
LAST-MODIFIED:20240322T063634Z
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