Reconstitution of mammalian life cycle in vitro

Date

Jul 9, 2024

Time

11:00 AM - 12:00 PM

Speaker

Nobuhiko Hamazaki

Affiliation

University of Washington, Seattle, WA, USADepartments of Obstetrics & GynecologyDepartments of Genome SciencesInstitute for Stem Cell & Regenerative MedicineBrotman Baty Institute

Language

en

Main Topic

Biologie

Host

Jesse Veenvliet

Description

Mammalian development is still enigmatic processes as it undergoes all the process in mother's uterus. Historically, simply taking any part of the processes out from the uterus to dish has brought tremendous findings. For example, in vitro fertilization and the subsequent culture of embryos up to the blastocyst stage have given us the opportunity to monitor, manipulate, and investigate post-fertilization development.Here we will introduce two in vitro model systems: directly induced oocyte-like cells (DIOLs) and human advanced gastruloid model, which recapitulates mouse oocyte development and human post-gastrulation development, respectively, entirely in vitro. These systems provide robust and scalable platforms for investigating the mechanisms underlying mammalian life cycles, as well as failures in these processes, including infertility and developmental diseases.

Last modified: Jul 10, 2024, 7:40:14 AM