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UID:DSC-21325
DTSTART;TZID=Europe/Berlin:20241107T110000
SEQUENCE:1730967292
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20241107T120000
URL:https://dresden-science-calendar.de/calendar/en/detail/21325
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Götz: Organellar heterogeneity in development\, disease and repair
CLASS:PUBLIC
DESCRIPTION:Speaker: Magdalena Götz\nInstitute of Speaker: Helmholtz Zentr
 um Munich\nTopics:\n\n Location:\n  Name: MPI-CBG (MPI-CBG: Auditorium Lar
 ge)\n  Street: Pfotenhauerstraße 108\n  City: 01307 Dresden\n  Phone: +49
  351 210-0\n  Fax: +49 351 210-2000\nDescription: In this presentation I w
 ill discuss a new layer of regulation in development and repair – namely
  organellar heterogeneity. Many organelles perform pan-cellular functions 
 and were hence considered to be rather similar between cell types. However
 \, we have recently identified an unexpected heterogeneity of organelles\,
  such as the centrosome\, the nucleolus or the mitochondria between even c
 losely related cell types\, such as neural stem cells and neurons revealin
 g or neurons and astrocytes. I will describe these discoveries and then ta
 lk about how this matters for development\, disease and repair. I will hig
 hlight how the localization of a ubiquitous splicing factor at the centros
 ome matters for correct neuronal positioning and how localization can expl
 ain why mutation of a ubiquitous protein has an organ-specific phenotype. 
 This will bring us to moonlighting proteins and I will share unpublished d
 ata on the role of a cytoskeleton-associated protein in the nucleus. In co
 ncluding I may briefly touch on mitochondrial heterogeneity and its role i
 n direct neuronal reprogramming including human astroglia-to neuron conver
 sion. Taken together\, our knowledge about basic mechanisms of neurogenesi
 s allowed making great strides towards neuronal repair.
DTSTAMP:20260812T171540Z
CREATED:20240925T144904Z
LAST-MODIFIED:20241107T081452Z
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