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CMCB Life Sciences Seminar: Prof. Steffen Jung, Weizmann Institute of Science, Dep. of Immunology & Regenerative Biology, Israel

Date
Dec 12, 2024
Time
1:00 PM - 2:00 PM
Series
CMCB Life Sciences Seminar
Language
en
Main Topic
Willkommen
Other Topics
Biologie, Willkommen
Description

Host: Michael Sieweke (CRTD)

Title: "Monocytes and Macrophages - origins matter..."

Abstract: Tissue-resident macrophages (TRM) comprise a conglomerate of cells that seeded tissues during fetal development and cells that derive postnatally from adult classical monocytes (CM). The degree of monocytic contribution differs among organs, related to their environmental exposure, physical stress, and history of challenges and age. Recent studies have shown that also CM are heterogeneous and can derive from distinct bone marrow precursors. We will discuss our recent evidence that this CM dichotomy translates into TRM heterogeneity. Moreover, we will report our finding that, unlike assumed, monocyte-derived microglia accumulate with age in healthy brains and why these cells present a risk factor for CNS for pathology.

Links

Last modified: Dec 12, 2024, 7:37:23 AM

Location

Center for Regenerative Therapies DresdenFetscherstraße10501307Dresden
Phone
+49 (0)351 458 82052
Fax
+49 (0)351 458 82059
E-Mail
TUD CRTD
Homepage
https://tu-dresden.de/cmcb/crtd

Organizer

Center for Molecular and Cellular Bioengineering (CMCB)01062Dresden
Phone
+49 351 463-40359
Fax
+49 351 463-40322
E-Mail
TUD CMCB
Homepage
https://tu-dresden.de/cmcb
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