Nuclear structure, function and homeostasis – from ribosome synthesis to chromatin organization

Date

May 22, 2025

Time

11:00 AM - 12:00 PM

Speaker

Ulrike Kutay

Affiliation

ETH Zurich

Series

MPI-CBG Thursday Seminar

Language

en

Main Topic

Biologie

Host

Alexander von Appen

Description

The Kutay lab investigates nuclear organization, function and dynamics in mammalian cells, including research on the biosynthetic function of the cell nucleus in the assembly of ribosomal subunits, the role of the nuclear envelope in nucleo-cytoplasmic communication and genome organization, and the dynamic remodelling of the nuclear compartment during the cell cycle. In my talk, I will present two aspects of our ongoing work. Firstly, I will address how we exploited data from genome-wide screens on ribosome synthesis to decipher how the ubiquitin-proteasome system safeguards ribosome synthesis. Secondly, I will present our work on the function of inner nuclear membrane proteins in chromatin organization and preservation of genome homeostasis in differentiated and pluripotent cells.

Last modified: May 22, 2025, 7:38:23 AM