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BiCoMaMe

Genetic mechanism of Bidirectional spontaneous transition and phenotypic equilibrium in populations of Breast cancer

Date
Dec 22, 2011
Time
2:30 PM - 3:30 PM
Speaker
Joseph Xu Zhou
Affiliation
Institute for Biocomplexity and Informatics, University of Calgary, Canada
Series
IMB - Seminar
Language
en
Main Topic
Biologie
Other Topics
Biologie, Informatik, Mathematik, Medizin
Host
Ingo Roeder
Description
Recently there exist extensive experiments to demonstrate the non-genetic phenotype transitions between cancer stem cells and non-stem cancer cells with or without drug treatment. More surprisingly, a phenotypic equilibrium in cancer cell population has been discovered after various cell sorting experiments. With a new theoretical framework to build a genetic landscape, we show that the phenotypic equilibrium comes from a genetic landscape underneath, and that cell ratio equilibrium shift comes from the induction de novo, not from selection of pre-existing heterogeneity of cancer cell population.

Last modified: Dec 19, 2011, 12:50:30 PM

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Location

Institut für Medizinische Informatik und Biometrie (IMB) (New location: Blasewitzer Strasse 86, 01307 Dresden, 3rd floor, R. 3.465)Blasewitzer Straße8601307Dresden
Homepage
http://tu-dresden.de/die_tu_dresden/fakultaeten/medizinische_fakultaet/inst/imb

Organizer

IMBMedizinsche Fakultät Carl Gustav Carus der TU Dresden, Fetscherstr.7401307Dresden
Phone
+49 351 3177 133
Fax
+49 351 3177 225
E-Mail
IMB
Homepage
http://tu-dresden.de/die_tu_dresden/fakultaeten/medizinische_fakultaet/inst/imb
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