260319_CMCB LSS - Dr Masahiro Ono, Imperial College London, UK
- Date
- Mar 19, 2026
- Time
- 1:00 PM - 2:00 PM
- Series
- CMCB Life Sciences Seminar
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- en
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- Willkommen
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- Biologie, Willkommen
- Description
Host: Karsten Kretschmer (CRTD
Title: “Investigating the Time Dimension of T Cells through Experiment and Computation”
Abstract: Immunological analyses often rely on static snapshots, which can miss the temporal dynamics of cell differentiation. We developed Tocky, a fluorescent timer–based system that visualizes T cell receptor signaling and gene expression dynamics in vivo. To interpret these high-dimensional data, we introduced computational tools that reconstruct flow cytometric Tocky readouts as temporal trajectories. Using a combined Tocky–CRISPR–machine learning framework, we identified temporal regulation of a critical enhancer in the Foxp3 locus, revealing how timing contributes to immune tolerance. Together, this approach enables quantitative dissection of the temporal logic underlying immune activation and regulation.
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Last modified: Mar 12, 2026, 7:37:30 AM
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