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UID:DSC-3808
DTSTART;TZID=Europe/Berlin:20120927T110000
SEQUENCE:1348731303
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20120927T120000
URL:https://dresden-science-calendar.de/calendar/en/detail/3808
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Iglesias: \"Biased excitable networks: how cells direct motion in r
 esponse to gradients\"
CLASS:PUBLIC
DESCRIPTION:Speaker: Pablo Iglesias\nInstitute of Speaker: Johns Hopkins Un
 iversity Baltimore\, MD\, USA\nTopics:\nBiologie\n Location:\n  Name: MPI-
 CBG (Seminar room Galleria)\n  Street: Pfotenhauerstraße 108\n  City: 013
 07 Dresden\n  Phone: +49 351 210-0\n  Fax: +49 351 210-2000\nDescription: 
 Chemotaxis\, the directed motion of cells in response to chemical gradient
 s\, requires the coordinated action of three different and separable proce
 sses: motility\, gradient sensing and polarization. Much effort has been e
 xpended understanding each of these processes\, and numerous mathematical 
 models have been proposed that explain each one. In this talk I will prese
 nt a comprehensive model that explains all three aspects of chemotaxis. Th
 e central element is the presence of a biased excitable system. This model
  takes into account reports that the actin cytoskeleton and other signalin
 g elements in motile cells have many of the hallmarks of an excitable medi
 um\, including the presence of propagating waves. This excitable behavior 
 can account for the spontaneous migration of cells. We suggest that the ch
 emoattractant-mediated signaling can bias excitability\, thus providing a 
 means by which cell motility can be directed. We also provide a mechanism 
 for cell polarity that can be incorporated into the existing framework.
DTSTAMP:20260615T025014Z
CREATED:20120919T073503Z
LAST-MODIFIED:20120927T073503Z
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