Cancelled: Inferring the developmental pathway of T-cell diversification from single-cell fate mapping

Date

Mar 7, 2013

Time

2:30 PM - 3:30 PM

Speaker

Thomas Höfer

Affiliation

DKFZ Heidelberg

Series

IMB - Seminar

Language

en

Main Topic

Biologie

Other Topics

Biologie, Medizin, Informatik

Host

IMB

Description

This talk has to be postponed and will be rescheduled. The inability to distinguish between inductive differentiation and selection in proliferating cell populations presents a principle obstacle to identifying cellular programs of cell-fate specification. Here we show that in-vivo fate mapping of the progenies of individual naive T cells during an immune response allows the identification of the differentiation program of effector and memory T cells. Long-lived, slowly proliferating memory precursors arise early and give rise to short-lived, rapidly proliferating effector cells. The resulting model provides a unifying mechanism for generating effector T cells in primary and recall immune responses and has implications for the design of vaccination.

Last modified: Mar 7, 2013, 1:54:27 PM