The complexity of pattern formation: The ocellar model case

Date

Apr 8, 2013

Time

2:00 PM - 3:00 PM

Speaker

Daniel Hidalgo

Affiliation

Andalusian Center for Developmental Biology (CABD)

Language

en

Main Topic

Physik

Other Topics

Physik

Host

Benjamin Friedrich

Description

Organogenesis has been widely studied for decades, both from theoretical and experimental perspectives. Every day a new gene related to organ formation with its genetic interactions are known, and the gene regulatory networks are increasingly complete and complex. Hence the need for mathematical theories capable of explaining the emergency of functional complexity that results in pattern formation. Since the birth of system biology, theoretics and experimentalists are joining forces more than ever applying modeling techniques to test biological behaviors and quantitative techniques to propose parametric validation. I will present our model of the ocellar complex development. This tissue patterning is fully dependent on the morphogen Hedgehog (Hh). We demonstrate that Hh diffusive molecule working as the source of a complex regulatory network clearly defines distinct differentiation regions needed to achieve the correct patterning. Our ocellar model defines the regulatory mechanisms that not only satisfies the wild type conditions but also predicts mutation behaviors. This indicates that our mathematical model can be used as a test bench for in silico experiments.

Last modified: Apr 8, 2013, 9:57:29 AM