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UID:DSC-636
DTSTART;TZID=Europe/Berlin:20110429T110000
SEQUENCE:1303832279
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20110429T120000
URL:https://dresden-science-calendar.de/calendar/en/detail/636
LOCATION:BioZ\, Tatzberg 47-4901307 Dresden
SUMMARY:Klein: Thymus epithelium and T cell tolerance
CLASS:PUBLIC
DESCRIPTION:Speaker: Ludger Klein\nInstitute of Speaker: Institute for Immu
 nology\, Ludwigs-Maximilians University Munich \nTopics:\nBiologie\, Mediz
 in\n Location:\n  Name: BioZ (5th floor\, conference rooms 1 & 2)\n  Stree
 t: Tatzberg 47-49\n  City: 01307 Dresden\n  Phone: \n  Fax: \nDescription:
  Tolerance to \"self\" is a fundamental property of the immune system\; it
 s breakdown can lead to autoimmune diseases such as multiple scleroris and
  diabetes. Selection processes in the thymus are essential for the generat
 ion of a self-tolerant T cell repertoire\, either through removal of poten
 tially dangerous T cells or through the induction of regulatory T cells. O
 ur aim is to understand how the thymic microenvironment orchestrates these
  cell fate decisions.    Publications:  Hinterberger M\, Aichinger M\, Pra
 zeres da Costa O\, Voehringer D\, Hoffmann R and Klein L (2010) Autonomous
  role of medullary thymic cells in central CD4+ T cell tolerance. Nature I
 mmunology 11(6):512-19    Aschenbrenner K\, D`Cruz LM\, Vollmann EH\, Hint
 erberger M\, Emmerich J\, Swee LK\, Rolink A and Klein L (2007) Selection 
 of FoxP3+ regulatory T cells specific for self-antigen expressed and prese
 nted by Aire+ medullary thymic epithelial cells. Nature Immunology 8(4):35
 1-58    D`Cruz L and Klein L (2005) Development and function of agonist in
 duced CD25+FoxP3+ regulatory T cells un the absence of Interleukin 2 signa
 ling. Nature Immunology 6(11):1152-59    Derbinski J\, Schulte A\, Kyewski
  B and Klein L (2001) \"Promiscuous\" gene expression in thymic medullary 
 epithelial cells mirrors the \"preipheral self\". Nature Immunology 2(11):
 1032-36
DTSTAMP:20260430T194454Z
CREATED:20110405T120319Z
LAST-MODIFIED:20110426T153759Z
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