Hereditary Photoreceptor Degeneration Temporal Characteristics and Cell Death Mechanisms

Date

Jul 4, 2014

Time

11:00 AM - 12:00 PM

Speaker

Dr. Francois Paquet-Durand, University of Tübingen, Institute of Ophthalmic Research

Series

CMCB Life Sciences Seminar

Language

en

Main Topic

Biologie

Other Topics

Biologie, Medizin

Host

Marius Ader, Mike Karl

Description

If you would like to talk to him, please get in contact with the hosts! Thank you.About Dr. Francois Paquet-Durand: Dr. Francois Paquet-Durand has made seminal contribution on elucidating the mechanisms of neuronal cell death, in particular in the context of a set of hereditary degenerative diseases of the retina, collectively referred to as Retinitis Pigmentosa (RP).RP eventually causes blindness and is to date untreatable. Contrary to common belief, in RP alternative, non-apoptotic cell death mechanisms appear to play a preeminent role. In his recent and future work he wants to improve the understanding of these mechanisms to develop novel treatments for these diseases.Currently, he is also coordinating a EU-FP7 project on drug development (www.drugsford.eu).Publications: 1. Sahaboglu A, et al., Paquet-Durand F. Retinitis pigmentosa: rapid neurodegeneration is governed by slow cell death mechanisms. Cell Death Dis, 4:e488, 2013.2. Trifunović D, et al., Paquet-Durand F: Neuroprotective Strategies for the Treatment of Inherited Photoreceptor Degeneration. Curr Mol Med, 12: 598-612, 2012.3. Jaumann M, et al., Paquet-Durand F, et al.: cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function. Nat Med, 18:252-9, 2012.4. Paquet-Durand F et al. A key role for cyclic nucleotide gated (CNG) channels in cGMP-related retinitis pigmentosa. Hum Mol Genet. 20115. Paquet-Durand F et al. Excessive activation of poly(ADP-ribose) polymerase contributes to inherited photoreceptor degeneration in the retinal degeneration 1 mouse. J Neurosci. 2007 Sep 19;27(38):10311-9.

Links

• to announcement of the organizer

Last modified: Jul 4, 2014, 10:04:19 AM