Embryonic-like skin regeneration in adult mammals: principles and mechanisms

Date

Oct 5, 2015

Time

11:00 AM - 12:00 PM

Speaker

Maksim Plikus, UCI, Department of Developmental and Cell Biology, University of California (UCI)

Series

CMCB Life Sciences Seminar

Language

en

Main Topic

Biologie

Other Topics

Biologie, Medizin

Host

Elly Tanaka

Description

About the research of Maksim Plikus: My laboratory studies regeneration in adult mammals. We use skin as the primary research model. In the normal skin we study how hundreds of thousands of hair follicles coordinate their regeneration cycles with one another. We show that organ-level management of regeneration can be achieved via the self-organization mechanism based on the Cellular Automata principle. In the wounded skin we study how de novo regeneration can be reactivated. We show that new skin can regenerate via mechanisms that partially replicate embryonic development. Publications: (1) Plikus MV, Mayer J, de la Cruz D, Baker R, Maini P, Maxson R, Chuong C (2008). Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration. Nature 451: 340-344 (2) Plikus MV, Baker R, Chen C, Fare C, de la Cruz D, Andl T, Maini P, Millar S, Widelitz R, Chuong C (2011). Self-organizing and stochastic behaviors during the regeneration of hair stem cells. Science. 332: 586-589. (3) Plikus MV, Vollmers C, De la Cruz D, Chaix A, Ramos R, Panda S, Chuong CM (2013) Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling. Proc Natl Acad Sci USA. 110: E2106–E2115. (4) Gay D, Kwon OS, Zhang Z, Burrows M, Plikus MV, Holler PD, Ito M, Yang Z, Treffeisen E, Kim CD, Nace A, Zhang X, Baratono S, Wang F, Ornitz DM, Millar SE, Cotsarelis G (2013). Fgf9 from dermal γδT cells induces hair follicle neogenesis after wounding. Nature Medicine. 19: 916-923. (5) c. Zhang LJ, Guerrero-Juarez CF, Hata T, Bapat SP, Ramos R, Plikus MV, Gallo RL (2015). Dermal adipocytes protect against invasive Staphylococcus aureus skin infection. Science 347: 67-71. http://www.ncbi.nlm.nih.gov/pubmed/25554785

Links

• to announcement of the organizer

Last modified: Oct 5, 2015, 9:51:28 AM