Nonlinear dynamics and phase space flows to understand the phase behavior of motor protein motion on antiparallel filaments

Datum

30.08.2016

Zeit

11:00 - 12:30

Sprecher

Hui-Shun Kuan

Zugehörigkeit

University of Colorado

Sprache

en

Hauptthema

Physik

Andere Themen

Physik

Host

UB

Beschreibung

Motor protein motion on biopolymers can be described by driven diffusive models related to the totally asymmetric exclusion process (TASEP). Inspired by recent experiments on the motion of kinesin-4 motors on antiparallel microtubule overlaps, we develop a model incorporating the TASEP on two antiparallel lanes with binding kinetics and lane switching. We determine the steady-state motor density profiles and phase diagram using phase space flows at the mean-field level. We compared our results to kinetic Monte Carlo simulations. Phases previously identified for the single-filament model occur in the limit of zero switching rate. In addition, lane switching couples the density profiles on the two lanes and can lead to a new phase not possible for a single filament: switching moves motors from the higher density lane to lower density lane, causing local jamming and creating multiple domain walls. We determine the phase diagram of the model and discuss the boundary layer length as a function of bulk motor concentration and motor speed.

Letztmalig verändert: 30.08.2016, 09:36:36