Bi

Single-cell delineation of lineage and genetic identity in the mouse brain

Datum
30.03.2023
Zeit
11:00 - 12:00
Sprecher
Christian Mayer
Zugehörigkeit
MPI of Neurobiology & MPI for Biological Intelligence Martinsried, Germany
Serie
MPI-CBG Thursday Seminar
Sprache
en
Hauptthema
Biologie
Host
Marino Zerial
Beschreibung
During neurogenesis, mitotic progenitor cells lining the ventricles of the embryonic mouse brain undergo their final rounds of cell division, giving rise to a wide spectrum of post-mitotic neurons and glia. The talk will discuss the link between developmental lineage and cell type diversity, which is still an open question in the field. We used massively parallel tagging of progenitors to track clonal relationships and transcriptomic signatures during mouse forebrain development. We quantified clonal divergence and convergence in all major cell classes of the mouse forebrain and found several types of GABAergic neurons that share a common lineage. Divergence of GABAergic clones occurred during embryogenesis at cell cycle exit, suggesting that differentiation into subtypes is initiated as a lineage-dependent process at the progenitor level. The talk will also discuss a mechanism by which selective enhancer activation is critical for establishing GABAergic projection neuron identity and potential pathological mechanisms.

Letztmalig verändert: 22.03.2023, 07:36:49

Veranstaltungsort

Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG Auditorium (big half))Pfotenhauerstraße10801307Dresden
Telefon
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de

Veranstalter

Max Planck Institute of Molecular Cell Biology and GeneticsPfotenhauerstraße10801307Dresden
Telefon
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de
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