Predicting mechanics of 3D epithelia in vertebrate embryonic development

Datum

01.06.2023

Zeit

11:00 - 12:00

Sprecher

Lisa Manning

Zugehörigkeit

Syracuse University, USA

Serie

MPI-CBG Thursday Seminar

Sprache

en

Hauptthema

Biologie

Host

Pierre Haas

Beschreibung

In vertebrates, the formation and maintenance of complex three-dimensional shapes in epithelia drives several important developmental processes. In addition, a collection of recent discoveries both in vivo and in vitro suggests that the collective mechanical response of a tissue (its fluidity or rheology) helps to control morphogenetic events. Therefore, there is a need to develop fully 3D biophysical models for epithelia that can predict or validate how global tissue mechanics impacts the structure and function of epithelia. In this talk, I will discuss several recent projects by our group and others to develop such models for specific model systems, including the left-right organizer in zebrafish and stratification and placode formation in mouse skin, where there are interesting interactions between cell shapes, epithelial architecture, and tissue fluidity. I will highlight how an interplay between models and experiments can help to drive a better mechanistic understanding of the processes that drive 3D tissue structure and function, especially when multiple mechanisms are operating at the same time.

Letztmalig verändert: 02.06.2023, 07:36:48