Bi

Predicting mechanics of 3D epithelia in vertebrate embryonic development

Datum
01.06.2023
Zeit
11:00 - 12:00
Sprecher
Lisa Manning
Zugehörigkeit
Syracuse University, USA
Serie
MPI-CBG Thursday Seminar
Sprache
en
Hauptthema
Biologie
Host
Pierre Haas
Beschreibung
In vertebrates, the formation and maintenance of complex three-dimensional shapes in epithelia drives several important developmental processes. In addition, a collection of recent discoveries both in vivo and in vitro suggests that the collective mechanical response of a tissue (its fluidity or rheology) helps to control morphogenetic events. Therefore, there is a need to develop fully 3D biophysical models for epithelia that can predict or validate how global tissue mechanics impacts the structure and function of epithelia. In this talk, I will discuss several recent projects by our group and others to develop such models for specific model systems, including the left-right organizer in zebrafish and stratification and placode formation in mouse skin, where there are interesting interactions between cell shapes, epithelial architecture, and tissue fluidity. I will highlight how an interplay between models and experiments can help to drive a better mechanistic understanding of the processes that drive 3D tissue structure and function, especially when multiple mechanisms are operating at the same time.

Letztmalig verändert: 02.06.2023, 07:36:48

Veranstaltungsort

Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG Auditorium)Pfotenhauerstraße10801307Dresden
Telefon
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de

Veranstalter

Max Planck Institute of Molecular Cell Biology and GeneticsPfotenhauerstraße10801307Dresden
Telefon
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de
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