Bi

Predicting mechanics of 3D epithelia in vertebrate embryonic development

Date
Jun 1, 2023
Time
11:00 AM - 12:00 PM
Speaker
Lisa Manning
Affiliation
Syracuse University, USA
Series
MPI-CBG Thursday Seminar
Language
en
Main Topic
Biologie
Host
Pierre Haas
Description
In vertebrates, the formation and maintenance of complex three-dimensional shapes in epithelia drives several important developmental processes. In addition, a collection of recent discoveries both in vivo and in vitro suggests that the collective mechanical response of a tissue (its fluidity or rheology) helps to control morphogenetic events. Therefore, there is a need to develop fully 3D biophysical models for epithelia that can predict or validate how global tissue mechanics impacts the structure and function of epithelia. In this talk, I will discuss several recent projects by our group and others to develop such models for specific model systems, including the left-right organizer in zebrafish and stratification and placode formation in mouse skin, where there are interesting interactions between cell shapes, epithelial architecture, and tissue fluidity. I will highlight how an interplay between models and experiments can help to drive a better mechanistic understanding of the processes that drive 3D tissue structure and function, especially when multiple mechanisms are operating at the same time.

Last modified: Jun 2, 2023, 7:36:48 AM

Location

Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG Auditorium)Pfotenhauerstraße10801307Dresden
Phone
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de

Organizer

Max Planck Institute of Molecular Cell Biology and GeneticsPfotenhauerstraße10801307Dresden
Phone
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de
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