Seminar: Microdosimetry of kidney cells exposed to 243Am and X-ray irradiation (Pia Kahle)

Datum

04.07.2024

Zeit

15:00 - 16:00

Sprache

en

Hauptthema

Willkommen

Andere Themen

Physik, Willkommen

Beschreibung

In vitro experiments with rat kidney cells (NRK-52E) exposed to 243 Am in cell culture medium show a decreasing cell viability with increasing americium concentration. Both the chemical cytotoxicity of americium and the dose caused by ionizing radiation have to be considered as possible causes. To determine the dose rate, the influence of α-, β- and γ- radiation was examined intra- and extracellularly in a detailed microdosimetric model. In the in vitro experiments, the dose rate is essentially caused by extracellular α-radiation. At the americium concentrations used, dose rates up to the Gy/h range were achieved. Noteworthy the geometry of the cells is a crucial parameter. In addition, reference samples of untreated kidney cells were exposed to analog doses in an X-ray field. The cell viability curves depending on the dose show good agreement for both approaches. In this presentation, both the microdosimetric calculations and the experimental cell irradiation possibilities at the Institute for Nuclear and Particle Physics will be presented.

Links

• Termindetails auf den Webseiten der TU Dresden (https://tu-dresden.de)

Letztmalig verändert: 04.07.2024, 07:40:08