Organellar heterogeneity in development, disease and repair

Datum

07.11.2024

Zeit

11:00 - 12:00

Sprecher

Magdalena Götz

Zugehörigkeit

Helmholtz Zentrum Munich

Serie

MPI-CBG Thursday Seminar

Sprache

en

Hauptthema

Biologie

Host

Meri Huch

Beschreibung

In this presentation I will discuss a new layer of regulation in development and repair – namely organellar heterogeneity. Many organelles perform pan-cellular functions and were hence considered to be rather similar between cell types. However, we have recently identified an unexpected heterogeneity of organelles, such as the centrosome, the nucleolus or the mitochondria between even closely related cell types, such as neural stem cells and neurons revealing or neurons and astrocytes. I will describe these discoveries and then talk about how this matters for development, disease and repair. I will highlight how the localization of a ubiquitous splicing factor at the centrosome matters for correct neuronal positioning and how localization can explain why mutation of a ubiquitous protein has an organ-specific phenotype. This will bring us to moonlighting proteins and I will share unpublished data on the role of a cytoskeleton-associated protein in the nucleus. In concluding I may briefly touch on mitochondrial heterogeneity and its role in direct neuronal reprogramming including human astroglia-to neuron conversion. Taken together, our knowledge about basic mechanisms of neurogenesis allowed making great strides towards neuronal repair.

Letztmalig verändert: 07.11.2024, 09:14:52