Bi

Organellar heterogeneity in development, disease and repair

Date
Nov 7, 2024
Time
11:00 AM - 12:00 PM
Speaker
Magdalena Götz
Affiliation
Helmholtz Zentrum Munich
Series
MPI-CBG Thursday Seminar
Language
en
Main Topic
Biologie
Host
Meri Huch
Description
In this presentation I will discuss a new layer of regulation in development and repair – namely organellar heterogeneity. Many organelles perform pan-cellular functions and were hence considered to be rather similar between cell types. However, we have recently identified an unexpected heterogeneity of organelles, such as the centrosome, the nucleolus or the mitochondria between even closely related cell types, such as neural stem cells and neurons revealing or neurons and astrocytes. I will describe these discoveries and then talk about how this matters for development, disease and repair. I will highlight how the localization of a ubiquitous splicing factor at the centrosome matters for correct neuronal positioning and how localization can explain why mutation of a ubiquitous protein has an organ-specific phenotype. This will bring us to moonlighting proteins and I will share unpublished data on the role of a cytoskeleton-associated protein in the nucleus. In concluding I may briefly touch on mitochondrial heterogeneity and its role in direct neuronal reprogramming including human astroglia-to neuron conversion. Taken together, our knowledge about basic mechanisms of neurogenesis allowed making great strides towards neuronal repair.

Last modified: Nov 7, 2024, 9:14:52 AM

Location

Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG: Auditorium Large)Pfotenhauerstraße10801307Dresden
Phone
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de

Organizer

Max Planck Institute of Molecular Cell Biology and GeneticsPfotenhauerstraße10801307Dresden
Phone
+49 351 210-0
Fax
+49 351 210-2000
E-Mail
MPI-CBG
Homepage
http://www.mpi-cbg.de
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