Perfect Adaptation in Biological Networks

Datum

18.05.2026

Zeit

15:30 - 16:30

Sprecher

Prof Mustafa Khammash

Zugehörigkeit

ETH Zürich

Serie

MPI-PKS Kolloquium

Sprache

en

Hauptthema

Physik

Andere Themen

Physik

Beschreibung

A distinctive feature of many biological systems is their ability to adapt to persistent stimuli or disturbances that would otherwise drive them away from a desirable steady state. This resulting stasis enables reliable function across a wide range of external environments. We focus on a stringent form of this behavior—robust perfect adaptation (RPA)—which remains resilient to certain network and parameter perturbations. As in engineered control systems, RPA is not incidental: it requires the regulating network to satisfy specific, unavoidable structural constraints. Using examples from systems biology and synthetic biology, we show how these constraints arise in natural and engineered circuits. We argue that identifying the structural basis of RPA allows us to move beyond implementation details and provides a principled lens for understanding regulatory complexity and information processing in biological systems

Letztmalig verändert: 07.03.2026, 07:37:36