Impact of tumor microenvironment on radiation response in human head and neck squamous cell carcinomas (hSCC) growing in nude mice

Datum

03.02.2011

Zeit

14:30 - 15:30

Sprecher

Ala Yaromina

Zugehörigkeit

Center for Radiation Research in Oncology Dresden

Sprache

en

Hauptthema

Medizin

Andere Themen

Biologie, Physik, Medizin

Host

Ingo Roeder

Beschreibung

There are many factors known to affect radiation response to fractionated irradiation. Among intrinsic radiosensitivity, number of cancer stem cells, etc. tumor microenvironment plays an important role. The impact of hypoxia, perfusion, vasculature, etc. before and during fractionated irradiation on radiation response was investigated in a panel of hSCC transplanted in vivo. Histological methods were used to evaluate microenvironmental parameters. Radiation response after clinically relevant fractionated irradiation with 30 fractions within 6 weeks was quantified in terms of TCD50, i.e. dose to cure 50% of tumors. Overall, it appears that the prognostic value of tumor microenvironment can be improved if measurements are made during fractionated irradiation.

Letztmalig verändert: 31.01.2011, 19:03:01