Impact of tumor microenvironment on radiation response in human head and neck squamous cell carcinomas (hSCC) growing in nude mice

Date

Feb 3, 2011

Time

2:30 PM - 3:30 PM

Speaker

Ala Yaromina

Affiliation

Center for Radiation Research in Oncology Dresden

Language

en

Main Topic

Medizin

Other Topics

Biologie, Physik, Medizin

Host

Ingo Roeder

Description

There are many factors known to affect radiation response to fractionated irradiation. Among intrinsic radiosensitivity, number of cancer stem cells, etc. tumor microenvironment plays an important role. The impact of hypoxia, perfusion, vasculature, etc. before and during fractionated irradiation on radiation response was investigated in a panel of hSCC transplanted in vivo. Histological methods were used to evaluate microenvironmental parameters. Radiation response after clinically relevant fractionated irradiation with 30 fractions within 6 weeks was quantified in terms of TCD50, i.e. dose to cure 50% of tumors. Overall, it appears that the prognostic value of tumor microenvironment can be improved if measurements are made during fractionated irradiation.

Last modified: Jan 31, 2011, 7:03:01 PM