Extramitochondrial ATP synthesis: new insights on visual transduction, nervous conduction, memory, sleep neurodegenerative diseases and cancer.

Date

Oct 22, 2015

Time

4:00 PM - 5:00 PM

Speaker

Professor Alessandro Morelli, Università degli Studi di Genova, Dipartimento di Farmacia (DIFAR)

Series

CMCB Life Sciences Seminar

Language

en

Main Topic

Biologie

Other Topics

Biologie, Medizin

Host

Prof. R.H.W. Funk, Institute for Anatomy, Faculty of Medicine Carl Gustav Carus, TU Dresden

Description

About the research of Professor Morelli: At the present, it is known that oxidative phosphorylation machinery (OXPHOS) is located in the mitochondrial inner membrane but, in the last years, several studies demonstrated its ectopic localitation in numerous mammalian cell membranes, suggesting an extramitochondrial ATP production to supply cell processes. OXPHOS proteins would get to the extra-mitochondrial respiring membranes through heterologous fusion of mitochondria with endoplasmic reticulum, then following the pathway of membrane secretion. Such data shed new light on visual transduction, neural conduction supported by myelin, the bioenergetics of plasma cells, platelets, helping to understand their metabolism prompting to the formulation of new paradigms in many fields of biology. Publications: 1. Bartolucci M, Ravera S, Garbarino G, Ramoino P, Ferrando S, Calzia D, Candiani S, Morelli A, Panfoli I. Functional Expression of Electron Transport Chain and F(o)F (1)-ATP Synthase in Optic Nerve Myelin Sheath. Neurochem Res. 2015 Sep 3. [Epub ahead of print] PubMed PMID: 26334391. 2. Ravera S, Bartolucci M, Adriano E, Garbati P, Ferrando S, Ramoino P, Calzia D, Morelli A, Balestrino M, Panfoli I. Support of Nerve Conduction by Respiring Myelin Sheath: Role of Connexons. Mol Neurobiol. 2015 Jun 2. [Epub ahead of print] PubMed PMID: 26033217. 3. Ravera S, Bartolucci M, Cuccarolo P, Litamè E, Illarcio M, Calzia D, Degan P, Morelli A, Panfoli I. Oxidative stress in myelin sheath: The other face of the extramitochondrial oxidative phosphorylation ability. Free Radic Res. 2015;49(9):1156-64. doi: 0.3109/10715762.2015.1050962. Epub 2015 Jun 4. PubMed PMID: 25971447. 4. Morelli AM, Ravera S, Calzia D, Panfoli I. Hypothesis of lipid-phase-continuity proton transfer for aerobic ATP synthesis. J Cereb Blood Flow Metab. 2013 Dec;33(12):1838-42. doi: 10.1038/jcbfm.2013.175. Epub 2013 Oct 2. PubMed PMID: 24084698; PubMed Central PMCID: PMC3851912. 5. Calzia D, Barabino S, Bianchini P, Garbarino G, Oneto M, Caicci F, Diaspro A, Tacchetti C, Manni L, Candiani S, Ravera S, Morelli A, Enrico Traverso C, Panfoli I. New findings in ATP supply in rod outer segments: insights for retinopathies. Biol Cell. 2013 Aug;105(8):345-58. doi: 10.1111/boc.201300003. Epub 2013 Jun 18. PubMed PMID: 23659850.

Links

• to announcement of the organizer

Last modified: Oct 22, 2015, 9:54:42 AM