Institutskolloquium (FWP) "Lactate transport as a target for cancer therapy"

Date

Sep 11, 2017

Time

3:00 PM - 4:00 PM

Speaker

Lester R. Drewes

Affiliation

PhD,Department of Biomedical Sciences, University of Minnesota Medical School Duluth, Duluth, Minnesota, USA

Language

en

Main Topic

Willkommen

Other Topics

Physik

Host

Prof. Dr. Peter Brust (FWPN, Tel. 0341-2341794610)

Description

Altered metabolism is a common feature of malignant tumors and associated stromal cells. Through induction of robust glycolysis, production of lactic acid is enhanced as is synthesis of substrates supporting cell proliferation. To eliminate excess lactic acid, cells express integral membrane proteins known as monocarboxylic acid transporters. Specifically, MCT1 and MCT4, two members of the SLC16A family, are induced several fold in cancer cells and often correlate with proliferation, metastasis and poor patient prognosis. Therefore, these transporters are targets for anticancer agents designed to block or disrupt lactic acid transport and reduce cell growth and viability. Over 300 small molecule inhibitors have been synthesized and evaluated in both in vitro and in vivo tumor models to characterize their properties and potential usefulness in the cancer field.

Last modified: Sep 11, 2017, 9:45:05 AM