450 Million Years of T cell Leukemia: Models and Drug Screens in Zebrafish

Date

Oct 7, 2011

Time

11:00 AM - 12:00 PM

Speaker

Nikolaus S. Trede

Affiliation

The Huntsman Cancer Institute, University of Utah

Series

CMCB Life Sciences Seminar

Language

en

Main Topic

Medizin

Other Topics

Medizin

Host

Michael Brand

Description

The lab of Nikolaus Trede is focused on pathologic T lymphocyte development using the zebrafish model. The two main areas of study are models of T cell immunodeficiency and T acute lymphoblastic leukemia (T-ALL). The Trede lab has generated a number of mutant zebrafish lines that have defects in T cell and/or thymus development, and has mapped and positionally cloned several of these. They have also identified three mutant lines with heritable predisposition to T-ALL. These models were used to determine high-risk T-ALL signatures based on gene expression, copy number aberrations and epigenetic changes. Exploiting the versatility of our T cell reporting transgenic zebrafish line, we have also conducted a small molecule screen designed to identify new drugs with anti-T-ALL activity. This screenresulted in the identification of Lenaldekar with selective activities against hematologic malignancies.

Last modified: Sep 28, 2011, 5:00:42 PM