Electronic Nano-biosensors Based on Graphene Transistors

Date

Jul 4, 2024

Time

1:00 PM - 3:00 PM

Speaker

Zhaoli Gao

Affiliation

Chinese University of Hong Kong

Series

TUD nanoSeminar

Language

en

Main Topic

Physik

Other Topics

Physik

Host

Arezoo Dianat

Description

Probing biosystems with two-dimensional (2D) materials provides tremendous opportunities for highly sensitive detection of physiological properties at the molecular level, which can pave the way toward early-stage disease diagnosis and improved healthcare outcomes. In this talk, I will introduce the process we have developed for scalable fabrication of 2D-biosensor arrays for multiplexed detection of disease biomarkers, where a graphene field effect transistor (GFET) is utilized for signal transduction, and a biomolecular layer, e.g., protein, nuclide acid, serves as the biological recognition element. Further, integrating the hybridization chain reaction (HCR) process with GFET readout leads to oligonucleotide detection with sensitivity at the aM level. Looking to the future, I will discuss the synthesis of crystalline multilayer graphene and transition metal dichalcogenide materials with band gaps, providing a pathway toward next-generation biosensors with even greater sensitivity. Finally, I will discuss the ongoing development of a universal sensing platform based on aptamer-GFET biosensors that is potentially useful for wearable electronics for detecting health and performance biomarkers in sweat. Probing biosystems with two-dimensional (2D) materials provides tremendous opportunities for highly sensitive detection of physiological properties at the molecular level, which can pave the way toward early-stage disease diagnosis and improved healthcare outcomes. In this talk, I will introduce the process we have developed for scalable fabrication of 2D-biosensor arrays for multiplexed detection of disease biomarkers, where a graphene field effect transistor (GFET) is utilized for signal transduction, and a biomolecular layer, e.g., protein, nuclide acid, serves as the biological recognition element. Further, integrating the hybridization chain reaction (HCR) process with GFET readout leads to oligonucleotide detection with sensitivity at the aM level. Looking to the future, I will discuss the synthesis of crystalline multilayer graphene and transition metal dichalcogenide materials with band gaps, providing a pathway toward next-generation biosensors with even greater sensitivity. Finally, I will discuss the ongoing development of a universal sensing platform based on aptamer-GFET biosensors that is potentially useful for wearable electronics for detecting health and performance biomarkers in sweat.

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Last modified: Jul 4, 2024, 7:40:05 AM