Mathematical models of feedback regulation in cells and tissues

Date

Apr 14, 2011

Time

2:30 PM - 3:30 PM

Speaker

Lutz Brusch

Affiliation

Leader of the junior research group "SPACESYS", ZIH TU Dresden

Series

IMB - Seminar

Language

de

Main Topic

Medizin

Other Topics

Biologie, Medizin

Host

Ingo Roeder

Description

Feedback regulation is ubiquitous in nature, starting already at the molecular scale and extending all the way up often linking different scales. Biological systems utilise feedback regulation to let functions self-organise. Models of feedback regulation are inherently nonlinear and only fully disclose their secrets through bifurcation analysis. Typical system behaviours as a result of feedback regulation are (i) homeostasis, which I will illustrate with an example from growth factor signaling pathways that must not remain activated indefinitely or cause tumors otherwise [1], (ii) multistability, as it generates intracellular membrane identity [2], (iii) oscillations, as during vertebrate segmentation and (iv) complex behaviour en route to chaos like Calcium bursts that encode signals [3]. I'll close with an outlook on the spatio-temporal counterparts of the four types of behaviour. [1] Nakakuki et al. (2010) Ligand-Specific c-Fos Expression Emerges from the Spatiotemporal Control of ErbB Network Dynamics. Cell 141, 884-896. [2] del Conte-Zerial et al. (2008) Membrane identity and GTPase cascades regulated by toggle and cut-out switches. Mol. Syst. Biol. 4, 206. [3] Brusch et al. (2002) Fold-Hopf bursting in a model for calcium signal transduction. Z. Phys. Chem. 216, 487-497.

Last modified: Mar 25, 2011, 6:12:27 PM