The Edge of the Nucleus
- Date
- Mar 14, 2014
- Time
- 10:30 AM - 11:30 AM
- Speaker
- Donald and Ada Olins, University of New England, USA
- Language
- en
- Main Topic
- Willkommen
- Other Topics
- Willkommen
- Host
- Jochen Guck
- Description
- Our studies have focused upon the chromatin adjacent to the nuclear envelope (NE). Most experiments have been conducted with the human leukemia HL-60 cell line, which can be differentiated in vitro. The granulocyte forms exhibit ELCS (envelope-limited chromatin sheets) connecting the nuclear lobes. Evidence is presented that ~10 nm chromatin fibers adjacent to the NE are organized into a crisscross pattern that resembles ~30 nm fibers. Epichromatin, the surface chromatin, in all the HL-60 cell states has unique immunological properties that have been exploited for ChIP-Seq analyses. Epichromatin appears to be highly enriched in retrotransposon Alu, and exhibits spatial patterns that are chromosome specific and independent of the state of cell differentiation.
- Links
Last modified: Mar 14, 2014, 8:42:23 AM
Location
BioInnovationsZentrumDresden (BIOTEC, 5th Floor)Tatzberg47-4901307Dresden
Organizer
Biotechnologisches Zentrum der TU DresdenTatzberg47-4901307Dresden
- Phone
- +49 (0)351 463 40054
- Fax
- +49 (0)351 458 82059
- TUD BIOTEC
- Homepage
- https://tu-dresden.de/cmcb/biotec
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